Adenoviruses get safe, effective and specific

Specific immunotherapy in children is safe and effective.

Sequential transcriptional changes dictate safe and effective antigen-specific immunotherapy

Antigen-specific immunotherapy combats autoimmunity or allergy by reinstating immunological tolerance to target antigens without compromising immune function. Optimization of dosing strategy is critical for effective modulation of pathogenic CD4(+) T-cell activity. Here we report that dose escalation is imperative for safe, subcutaneous delivery of the high self-antigen doses required for effec...

Is "safe effective glucose control" effective and safe?

Of note, the randomized controlled trials that showed a benefit from glucose control have tested only one and the same BGL target (4.4 to 6.1 mmol/l [80 to 110 mg/dl]) [2,3]. In addition, in these trials conventional insulin treatment was administered only when the BGL was >12 mmol/L (215 mg/dl), with insulin infusion gradually decreased and stopped when the BGL fell to <10 mmol/l (180 mg/dl). ...

Is Safe and Effective

18 This issue marks the beginning of a new section of the Journal, the “Bioethics and Law Forum.” As its first editor. I am pleased to see the level of interest in ethical and legal issues related to issues in infertility and can predict that there will be no shortage of interesting and provocative questions addressed in the “Forum” in the upcoming months. The articles appearing this month are ...

Safe and Effective Contracts

This dissertation introduces a framework enabling the dynamic verification of expressive specifications. Inspired by formal verification methods, this framework supports assertion, framing, and separation contracts. Assertion contracts specify what code should do, whereas framing contracts specify what code must not do. Separation contracts, inspired by separation logic, combine an explicit ass...